A study on the quality of life among stroke survivors: A cross sectional study

Background: The World Health Organization defines - Health as a “state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity.” Methodology: A cross sectional study on 96 patients with stroke aged more than 30 years was carried out NIMS Hospital, Jaipur for a period of 4 months from 1st January 2018 to 30th April 2018. Results: Out of 96 patients, Mean quality of score of patients with stroke was 65.04±9.982 there was significant difference seen in quality of life score according to sex, side of lesion, duration of stroke, socioeconomic status, occupation and hypertension. Conclusions: It can be said that quality of life is a multidimensional concept. As stroke cases is among the most devastating of health aspect, having multiple and profound effects upon all aspects of life, hence evaluation of quality of life is very important. Each and every effort should be made to improve these aspects and in turn to activity daily living (ADL) and improve the overall quality of stroke patients

Biomedical Event Trigger Identification Using Bidirectional Recurrent Neural Network Based Models

Biomedical events describe complex interactions between various biomedical entities. Event trigger is a word or a phrase which typically signifies the occurrence of an event. Event trigger identification is an important first step in all event extraction methods. However many of the current approaches either rely on complex hand-crafted features or consider features only within a window. In this paper we propose a method that takes the advantage of recurrent neural network (RNN) to extract higher level features present across the sentence. Thus hidden state representation of RNN along with word and entity type embedding as features avoid relying on the complex hand-crafted features generated using various NLP toolkits. Our experiments have shown to achieve state-of-art F1-score on Multi Level Event Extraction (MLEE) corpus. We have also performed category-wise analysis of the result and discussed the importance of various features in trigger identification task.Comment: The work has been accepted in BioNLP at ACL-201

Adenosine deaminase production by an endophytic bacterium (Lysinibacillus sp.) from Avicennia marina

The present study was carried out with the following objectives: (1) to isolate the endophytic bacilli strains from the leaves of mangrove plant Avicennia marina, (2) to screen the potential strains for the production of adenosine deaminase, (3) to statistically optimize the factors that influence the enzyme activity in the potent strain, and (4) to identify the potent strain using 16S rRNA sequence and construct its phylogenetic tree. The bacterial strains isolated from the fresh leaves of a mangrove A. marina were assessed for adenosine deaminase activity by plating method. Optimization of reaction process was carried out using response surface methodology of central composite design. The potent strain was identified based on 16S rRNA sequencing and phylogeny. Of five endophytic strains, EMLK1 showed a significant deaminase activity over other four strains. The conditions for maximum activity of the isolated adenosine deaminase are described. The potent strain EMLK1 was identified as Lysinibacillus sp. (JQ710723) being the first report as a mangrove endophyte. Mangrove-derived endophytic bacillus strain Lysinibacillus sp. EMLK1 is proved to be a promising source for the production of adenosine deaminase and this enzyme deserves further studies for purification and its application in disease diagnosis

Ultra fine chromite concentration using spiral concentrator

The conventional chromite beneficiation circuit utilises spiral concentrator for recovering chromite fines and as its efficiency decreases with respect to the decrease in particle size. Pilot scale studies have been performed to understand the effect of different process parameters which influence the separation of ultra fine chromite fines from a typical plant tailing. The process parameters of spiral concentrator such as feed rate (m3/hr), feed pulp density (% solids by weight) and splitter position (cm) are considered for the study. Splitter position has major influence on both grade and recovery of the concentrate fraction of spiral concentrator. Maximum grade of 48.54% Cr2O3 can be achieved in the concentrate fraction of spiral concentrator with 20.41% Cr2O3 recovery. Performance of spiral concentrator at different combination of process parameters was analysed with 3D surface plots

Butea monosperma Reduces Haloperidol and Sulpiride Induced Hyperprolactinemia in Rats

Background: Prolonged administration of neuroleptic drugs cause disrupted D dopamine receptor which leads to increased prolactin level, causes gyanaecomastia. Presently, dopamine receptor agonist is the choice of treatment for hyperprolactinemia. Aim and Objectives: The study aims to determine the antihyperprolactinemic effect of methanolic extract of Butea monosperma (MEBM) against haloperidol (HPL) and sulpiride (SPD) induced hyperprolactinemia and to correlate with its active constituents. Material and Methods: To induce hyperprolactinemia HPL 5 mg/kg for 16 continuous days and SPD 20 mg/kg for 28 continuous days was administred. MEBM 200 mg/kg/day and 400 mg/kg/day were administered for 16 and 28 days respectively half an hour before administration of HPL and SPD. The serum prolactin (PRL) level, dopamine (DA) level and antioxidant status in the rat brain, hematological parameters were measured and histological examination of the anterior pituitary gland, adrenal gland and spleen were done. In addition, antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT) were also estimated. Results: MEBM decreases serum PRL level and increased DA level in brain significantly. Further, MEBM also restored SOD and CAT status significantly. The inflammatory markers induced by HPL and SPD were suppressed by MEBM. Discussion: Neuronal DA inhibition by neuroleptic drugs decreases the release of DA which leads to hyperprolactinemia. MEBM (butrin) may activate DA neurones to ameliorate hyperprolactinaemia. The dopaminergic, anti-oxidant and anti-inflammatory effect of MEBM may be attributed to its anti-hyperprolactinemic effect. Conclusion: Butea monosperma possesses anti-hyperprolactinemic effect which may be attributed to its marker constituent like Butrin

Influence of shaking table process parameters on concentration of chromite plant tailings

Conventional chromite beneficiation plants of India discards large tonnage of chromite values as plant tailing. In the present investigation, a typical chromite beneficiation plant tailing of Sukinda region has investigated by using wet shaking table for the effective utilisation of the natural resource. In this context, the effect of different process variables such as wash water flow rate, deck tilt angle and feed flow rate has analysed. The interactional effects between different process variables has analysed in terms of 3D response surface plots. It was found that the Cr2O3 content has improved to 61.37% from a feed assaying 24.26%. It was envisaged that deck tilt angle has influence major on both grade and recovery of concentrate fraction of shaking table and in case of interactional effects, the interaction between deck tilt angle and feed flow rate has major influence compared to the others. Second order quadratic equations have developed for the prediction of grade and recovery of concentrate fraction of shaking table